« Human infection by avian influenza A H5N1. | Main | Preparing for pandemic vaccination: an international policy agenda for vaccine development. »

August 05, 2005

Analysis of synonymous codon usage in H5N1 virus and other influenza A viruses.

Biosystems. 2005 Jul; 81(1): 77-86
Zhou T, Gu W, Ma J, Sun X, Lu Z

In this study, we calculated the codon usage bias in H5N1 virus and performed a comparative analysis of synonymous codon usage patterns in H5N1 virus, five other evolutionary related influenza A viruses and a influenza B virus. Codon usage bias in H5N1 genome is a little slight, which is mainly determined by the base compositions on the third codon position. By comparing synonymous codon usage patterns in different viruses, we observed that the codon usage pattern of H5N1 virus is similar with other influenza A viruses, but not influenza B virus, and the synonymous codon usage in influenza A virus genes is phylogenetically conservative, but not strain-specific. Synonymous codon usage in genes encoded by different influenza A viruses is genus conservative. Compositional constraints could explain most of the variation of synonymous codon usage among these virus genes, while gene function is also correlated to synonymous codon usages to a certain extent. However, translational selection and gene length have no effect on the variations of synonymous codon usage in these virus genes.

Posted by dymaxion at August 5, 2005 02:30 PM

Comments

Post a comment




Remember Me?