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August 05, 2005

Highly Pathogenic H5N1 Influenza Virus Infection in Migratory Birds.

Science. 2005 Jul 6;
Liu J, Xiao H, Lei F, Zhu Q, Qin K, Zhang X, Zhang X, Zhao D, Wang G, Feng Y, Ma J, Liu W, Wang J, Gao GF

H5N1 avian influenza virus (AIV) has emerged as a pathogenic entity for a variety of species, including humans, in recent years. Here we report an outbreak among migratory birds on Lake Qinghaihu, China, in May and June 2005, in which hundreds of thousands of birds were affected. Pancreatic necrosis and abnormal neurological symptoms were the major clinical features. Sequencing of complete genomes of four H5N1 AIV strains isolated revealed to be reassortants related to a peregrine falcon isolate from Hong Kong and showed known "highly pathogenic" characteristics. Experimental animal infections reproduced typical highly pathogenic AIV-infection symptoms and pathology.

Posted by dymaxion at August 5, 2005 02:28 PM


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