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November 28, 2005

The Origins of Pandemic Influenza -- Lessons from the 1918 Virus

 
The Origins of Pandemic Influenza -- Lessons from the 1918 Virus (info)
Robert Belshe
The New England Journal of Medicine 353 (21), 2209-11 (24 Nov 2005)
The completion of the genetic sequencing of the 1918 influenza A virus by Taubenberger et al.1 and the subsequent recovery of the virus by Tumpey et al.2 using reverse genetic techniques are spectacular achievements of contemporary molecular biology and provide important insights into the origin of pandemic influenza. [snip] On the basis of the rates of replacement of amino acids, Taubenberger et al. estimated that avian influenza polymerase genes had been circulating in humans as early as 1900

Posted by dymaxion at November 28, 2005 01:36 PM

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